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Imagine your body as a complex machine that requires fuel to function properly. NMN and NAD+ are like two important components that help provide the energy your body needs to carry out its daily activities.

NMN is a molecule that is naturally found in the human body and certain foods. It is made up of nicotinamide (a form of vitamin B3) and ribose (a type of sugar molecule). When you consume NMN, your body can convert it into NAD+.

NAD+ is a coenzyme that plays a critical role in various cellular processes. It acts as a helper molecule that participates in many important reactions in your body, particularly those involved in energy metabolism. NAD+ helps convert the food you eat into energy that your cells can use. It's like the fuel that powers the cellular machinery.

As you age, the levels of NAD+ in your body naturally decline. This decline in NAD+ has been associated with aging and age-related conditions. By supplementing with NMN, which can be converted into NAD+, you can potentially boost your NAD+ levels and support cellular energy production.

Having adequate levels of NAD+ is important because it helps support the overall health and function of your cells. It is involved in processes like DNA repair, regulation of gene expression, and maintaining the health of your mitochondria (the energy-producing powerhouses of your cells). By supporting these cellular processes, NMN and NAD+ may have potential benefits for longevity, cellular function, and anti-aging.

So, in simple terms, NMN is a molecule that your body can convert into NAD+, which is essential for energy production and various cellular processes. By supplementing with NMN, you can potentially support your body's NAD+ levels and promote cellular health and function.

June 5, 2023 at 10:00:00 PM

NMN & NAD+

Energizing Elixir: Unleashing the Power of NMN and NAD+ for Cellular Vitality

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What are the Benefits of NMN & NAD+?

1. Enhanced Cellular Energy Production: NAD+ is a key player in cellular energy metabolism. By supporting NAD+ levels through NMN supplementation, it may help enhance energy production in cells, promoting vitality and overall physical performance.

2. Anti-Aging Effects: Declining NAD+ levels have been linked to aging. NMN supplementation has been shown to increase NAD+ levels in animal studies, which may help counteract age-related cellular decline and promote healthy aging.

3. DNA Repair and Maintenance: NAD+ is involved in DNA repair mechanisms, supporting the integrity and stability of your genetic material. By promoting NAD+ levels, NMN supplementation may contribute to DNA repair processes and help maintain cellular health.

4. Improved Mitochondrial Function: NAD+ plays a vital role in mitochondrial health and function. Mitochondria are responsible for generating cellular energy. By supporting NAD+ levels, NMN may help enhance mitochondrial efficiency and promote optimal cellular energy production.

5. Neuroprotective Effects: NAD+ is involved in various processes that support brain health and function. NMN supplementation has shown potential neuroprotective effects in preclinical studies, suggesting it may help protect against age-related cognitive decline and neurodegenerative diseases.

6. Cardiovascular Health: NAD+ is involved in maintaining the health and function of blood vessels and cardiac cells. By supporting NAD+ levels, NMN supplementation may help promote cardiovascular health and reduce the risk of age-related cardiovascular conditions.

7. Metabolic Regulation: NAD+ is involved in regulating metabolic processes, such as glucose and lipid metabolism. NMN supplementation may help support healthy metabolic function, potentially aiding in weight management and metabolic disorders.

8. Anti-Inflammatory Effects: NAD+ has been shown to regulate inflammation in the body. By promoting NAD+ levels, NMN supplementation may help modulate immune responses and reduce chronic inflammation, which is associated with various age-related diseases.

NMN & NAD+ in the World of Anti Aging

Acalah is driven by the belief that aging is not an inevitable process but rather a treatable condition. We are dedicated to pushing the boundaries of science and innovation to unlock the secrets of longevity. With our unwavering passion, we aim to revolutionize the field of anti-aging research and provide groundbreaking solutions. NMN (Nicotinamide Mononucleotide) and NAD+ (Nicotinamide Adenine Dinucleotide) play pivotal roles in the fight against aging. Here are some examples:

1. DNA Repair and Maintenance: NAD+ is involved in DNA repair mechanisms, which are essential for maintaining the integrity of your genetic material. By supporting NAD+ levels through NMN supplementation, it may help enhance DNA repair processes and counteract age-related DNA damage.

2. Cellular Energy Production: NAD+ is crucial for cellular energy metabolism. It plays a vital role in converting the food you eat into usable energy. By promoting NAD+ levels, NMN supplementation may help boost cellular energy production, providing vital energy to support optimal cellular function and counteract age-related energy decline.

3. Sirtuin Activation: NAD+ is a cofactor for sirtuins, a group of proteins involved in regulating cellular processes related to aging. Sirtuins play a role in various functions, including DNA repair, gene expression, and stress response. By supporting NAD+ levels, NMN supplementation may help activate sirtuins, leading to potential benefits for longevity and cellular health.

4. Mitochondrial Function: NAD+ is involved in maintaining mitochondrial health and function. Mitochondria are responsible for producing energy in cells and play a critical role in aging. NMN supplementation may help support NAD+ levels, contributing to optimal mitochondrial function and potentially slowing down age-related decline.

5. Reducing Oxidative Stress: NAD+ is involved in regulating cellular redox balance and reducing oxidative stress. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidants, is associated with aging and age-related diseases. NMN supplementation may help support NAD+ levels, promoting antioxidant defenses and reducing oxidative damage.

6. Cellular Communication: NAD+ is involved in cellular signaling and communication processes. It influences various signaling pathways involved in aging and age-related diseases. By supporting NAD+ levels, NMN supplementation may help maintain optimal cellular communication, promoting healthy cellular function and potentially slowing down age-related decline.

Here are some research papers.

1. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-471. doi:10.1016/j.tcb.2014.04.002

2. Mills KF, Yoshida S, Stein LR, et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013

3. Gomes AP, Price NL, Ling AJY, et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624-1638. doi:10.1016/j.cell.2013.11.037

4. de Picciotto NE, Gano LB, Johnson LC, et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016;15(3):522-530. doi:10.1111/acel.12461

5. Das A, Huang GX, Bonkowski MS, et al. Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging. Cell. 2018;173(1):74-89.e20. doi:10.1016/j.cell.2018.02.008

6. Yoshino J, Mills KF, Yoon MJ, et al. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014

7. Zhou CC, Yang X, Hua X, et al. Hepatic NAD+ deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br J Pharmacol. 2016;173(15):2352-2368. doi:10.1111/bph.13548

8. Trammell SAJ, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016;7:12948. doi:10.1038/ncomms12948

9. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. doi:10.1038/s41467-018-03421-7

10. Canto C, Houtkooper RH, Pirinen E, et al. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012;15(6):838-847. doi:10.1016/j.cmet.2012.04.022

11. Sinclair DA, Guarente L. Extrachromosomal rDNA circles--a cause of aging in yeast. Cell. 1997;91(7):1033-1042. doi:10.1016/s0092-8674(00)80494-7

12. Sinclair DA, Mills K, Denu JM. Aging in reverse: therapeutic potential of NAD+ and sirtuins in aging and age-related diseases. Cell Metab. 2014;19(2):176-187. doi:10.1016/j.cmet.2013.12.016

13. Zhang H, Ryu D, Wu Y, et al. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016;352(6292):1436-1443. doi:10.1126/science.aaf2693

14. Gomes AP, Price NL, Ling AJY, et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624-1638. doi:10.1016/j.cell.2013.11.037

15. Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016;17(11):679-690. doi:10.1038/nrm.2016.93

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